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Hard Fat/Mixed Fatty Acid Glycerides (Stearin)

Product description: We specialize in supplying pharmaceutical-grade Mixed Fatty Acid Glycerides (Hard Fat), fully compliant with CP, EP, and USP pharmacopoeia standards. Commonly utilized as a suppository base or sustain
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Mixed fatty acid glycerides serve as carriers, namely excipients, for suppositories. As suppositories represent a growing trend in the pharmaceutical industry, they align with the industry’s development principles of low toxicity and high efficacy, as well as public demands for medical care and health management, thus enjoying rapid market expansion. Accordingly, mixed fatty acid glycerides have become highly sought-after products. They are widely applied in various suppositories, such as hepatin suppositories, metronidazole hollow suppositories and naproxen microcapsule suppositories.

Mixed fatty acid glycerides generally refer to esters formed by glycerol and fatty acids (saturated or unsaturated). The mainstream commercial products are partial glycerides of stearic acid, oleic acid, lauric acid and ricinoleic acid. They are versatile non-ionic surfactants with large production volumes. Glycerol, also known as glycerin, contains three hydroxyl groups. When these hydroxyl groups react with fatty acids, monoglycerides, diglycerides and triglycerides are produced. High-carbon fatty acid glycerides are the main components of natural oils and fats.

Varying with the carbon number of fatty acids and the number of fatty molecules bound to glycerol, these glycerides exist in different forms: viscous liquids, semi-fluid gels, waxy solids and powders. They are odorless and tasteless, insoluble in water but soluble in organic solvents. Monoglycerides and diglycerides can form emulsions when shaken with water, while triglycerides have no emulsifying capacity. Therefore, fatty acid monoglycerides and diglycerides act as water-in-oil emulsifiers. They can interact with oils, proteins and carbohydrates, and are hydrolyzed under the action of acid, alkali or lipase to produce fatty acids and glycerol.

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